Purpose of this program:
To encourage basic and clinical biomedical research and research training and career development in diabetes, endocrinology and metabolic diseases. In diabetes research, to encourage biomedical research to develop a greater understanding of diabetes and the underlying mechanisms that cause diabetes and related complications and translate this understanding to new and improved therapies. Fundamental and clinical studies include the etiology, pathogenesis, prevention, diagnosis, treatment and cure of diabetes mellitus and its complications. In endocrine research, to encourage biomedical research on the normal and abnormal function of the pituitary, thyroid, parathyroid, adrenal, and other hormone secreting glands; on hormonal regulation of bone, adipose tissue, and liver; on fundamental aspects of signal transduction, including the action of hormones, coregulators, and chromatin remodeling proteins; on hormone biosynthesis, secretion, metabolism, and binding; and on hormonal regulation of gene expression and the role(s) of selective receptor modulators as partial agonists or antagonists of hormone action. In metabolic research, to encourage fundamental studies relevant to metabolic disorders including membrane structure, function, and transport phenomena and enzyme biosynthesis; and basic and clinical studies on the etiology, pathogenesis, prevention, and treatment of inherited metabolic disorders (such as cystic fibrosis). In training and career development, to support basic and clinical research training and support for career development and transition from postdoctoral biomedical research training to independent research related to diabetes, endocrinology and metabolic diseases. Small Business Innovation Research (SBIR) program: To expand and improve the SBIR program; To increase private sector commercialization of innovations derived from Federal research and development; to increase small business participation in Federal research and development and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. Small Business Technology Transfer (STTR) program: To stimulate and foster scientific and technological innovation through cooperative research and development carried out between small business concerns and research institutions; to foster technology transfer between small business concerns and research institutions to increase private sector commercialization of innovations derived from Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation.